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Actavis can be a NSAID that inhibits each isoforms of COX enzyme, a crucial enzyme linked to the inflammatory cascade. COX-one enzyme can be a constitutive enzyme linked to prostacyclin output and protective functions of gastric mucosa whereas COX-2 is definitely an inducible enzyme involved with the creation of inflammatory mediators in reaction to inflammatory stimuli. Actavis shows extra selectivity in the direction of COX-2 (IC50 of 0.77uM) than COX-1 (IC50 of >100uM), which promotes its gastric tolerance compared to other NSAIDs.

The principle route of elimination is by means of the urine where the elimination accounts for 70-80% of clearance with the drug . Close to two thirds from the administered dose is excreted by using the urine, generally as glucuronidated and hydroxylated kinds of aceclofenac . About 20% with the dose is excreted into feces . Pregnancy & Breastfeeding use

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• Actavis has the world’s only pharmaceutical producing facility totally driven by geothermal Electrical power.

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